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Prof. Anne-Marie ROUSSEL

医生 安娜玛丽•罗素教授


头衔 法国格勒诺布尔-阿尔卑斯大学生化系终身教授
领域 生化学

• Pharmacien, Docteur en Pharmacie, Docteur ès Sciences
• Professeur Émérite des Universités
• Discipline Biochimie Générale, Métabolique et Nutritionnelle Université Grenoble Alpes

课程:临床生理营养和功能医学
内容

课程内容

生理营养和功能医学,包括临床研究、生理学、生物学研究以及宏观和微量营养素不平衡的管理,同时考虑到它们的协同作用及其相互作用。我们身体的11种基本平衡水平中的作用,即膳食平衡、微生物群平衡、肠道通透性平衡、排毒平衡、氧化 – 炎症平衡、必需脂肪酸平衡、酸碱平衡、神经介质平衡、线粒体平衡、代谢和激素平衡、心理 – 行为平衡。此外,生理营养和功能医学包含了前沿的学科,比如:荷尔蒙营养。

目标

目标

① 提供真正的临床生理营养和功能医学咨询。
② 采用有科学依据的问卷调查为患者提供营养学、微营养学和内分泌方面的咨询。
③ 制定个性化营养和微营养管理计划。

课程

课程

学术论文

1994年10⽉份, 法国政府⼀次国家的⼤型的营养补充调查: “ SU.VI.MAX. ”. 由法国卫⽣局制定 Serge Hercberg医⽣负责。 该研究从1994年开始⼀直到2003年,历时8年。总共有13017位男性和⼥性,⼀组摄⼊每⽇摄⼊维C、维E、胡萝卜素、锌、以及硒。 结论发现: 通过每⽇摄⼊抗氧化微量元素,癌症发病率降低31%,意外伤亡降低37%。

该研究的微量元素定性,定量,以及效果跟踪是由格勒诺布尔⼤学⽣化系负责,安娜玛丽·罗素教授 也是团队负责⼈之⼀。

安娜玛丽·罗素教授作为欧洲首批研究生理营养以及微量元素的科学家,从微量元素到细胞能量系列产品的摄取,对妇⼥,对⽼年⼈,对⾼⽔平运动员,对病理性都有深入研究研究, 并在营养学、临床医学、病理学等各领域发表了大量论文。

  1. Stress exposure alters brain mRNA expression of the genes involved in insulin signalling, an effect modified by a high fat/high fructose diet and cinnamon supplement⾼糖⾼脂饮⻝下压⼒通过胰岛素反应对脑部mRNA(单链核糖核酸) 基因表达的改变 POLS ONE – 05/2018
  2. Frederic Canini / Bolin Qin / Anne Marie ROUSSEL 等多位. Positive effects of an oral supplementation by Glisodin, a gliadin-combined SOD rich melon extract, in an animal model of dietary-induced oxidative stress⼝服Gliosdin (⼀种法国甜⽠(Cucumis melo)中提取的超氧化歧化酶 (Superoxide Dismutase; SOD)由⼩⻨胶原蛋⽩(Gliadin)的⽣物⾼聚物包裹构成)动物实验上对降低氧化压⼒的有效帮助。Nutrition – 02/2015
  3. Isabelle Hininger / M. Osman / Anne-Marie Roussel等多位. Acute stress delays brain mitochondrial permeability transition pore opening Article. 压⼒对脑部线粒体的渗透性开⼝的影响.Journal of neurochemistry – 07/2014
  4. Cecile Batandier / Laurent Poulet / Anne Marie ROUSSEL / 等多位. Trace elements (zinc, selenium, chromium, iron), metabolic syndrome, and type 2 diabetes. 微量元素(锌,硒,铬,铁)在代谢类疾病、⼆型糖尿病的表达. Médecine des Maladies Métaboliques-01/2014
  5. Anne-Marie Roussel. Cinnamon Counteracts the Negative Effects of a High Fat/High Fructose Diet on Behavior, Brain Insulin Signaling and Alzheimer-Associated Changes. ⾁桂对⾼脂肪和⾼糖餐饮影响,脑部胰岛素信号和阿尔兹海默症的改变. Jounal of POLS online – 12/2013
  6. Richard A Anderson / Bolin Qin /Laurent Poulet / Anne-Marie Roussel等多位. Effects of a high-fat–high-fructose diet, stress and cinnamon on central expression of genes related to immune system, hypothalamic–pituitary–adrenocortical axis function and cerebral plasticity in rats. ⾼脂⾼糖饮⻝,压⼒以及⾁桂对免疫系统基因表达的影响,⼩⽩鼠脑下丘-脑垂体-肾上腺功能和脑部塑形模型. British Journal of Nutrition – 11/2013
  7. Nathalie Marissal-Arvy / Cecile Batandier / Anne Marie ROUSSEL – 等多位作者. Micronutrient status and cognitive decline in ageing. 微量元素对衰⽼过程中认知能⼒下降的影响. European Geriatric Medicine – 02/2011
  8. Monique Ferry / Anne-Marie Roussel.  Chrome et syndrome métabolique: Chromium and the metabolic syndrome. 铬元素对代谢病理的影响. Médecine des Maladies Métaboliques – 11/2009
  9. Anne-Marie Roussel. Micronutrient status and cognitive decline in ageing. 微量元素对衰⽼过程中认知能⼒下降的影响. European Geriatric Medicine – 02/2011
  10. Monique Ferry / Anne-Marie Roussel. Green Tea Extract Decreases Oxidative Stress and Improves Insulin Sensitivity in an Animal Model of Insulin Resistance, the Fructose-Fed Rat. ⼩⽩⿏⾼脂肪胰岛素模型 :茶叶提取降低氧化危害改善胰岛敏感度. Journal of the American College of Nutrition – 08/2009
  11. Isabelle Hininger / Rachida Benaraba / Sara Coves / Anne-Marie Roussel. Antioxidant Effects of a Cinnamon Extract in People with Impaired Fasting Glucose That Are Overweight or Obese ⾁桂的抗氧化能⼒在治疗超重超胖病⼈上的⽐较 Journal of the American College of Nutrition – 03/ 2009
  12. Anne-Marie Roussel / Isabelle Hininger / Rachida Benaraba / Richard A Anderson 等多位. Zinc supplementation does not alter plasma homocysteine, vitamin B12 and red blood cell folate concentrations in French elderly subjects. 法国⽼年⼈群锌摄⼊对⾎浆中同型半胱氨酸,维⽣素B12以及红细胞中天然叶酸的影响. Journal of Trace Elements in Medicine and Biology – 01/ 2009
  13. Véronique Ducros / Maud Andriollo / Josiane Arnaud/ Anne-Marie Roussel.  Fibrates but not statins increase plasma selenium in dyslipidemic aged patients – The EVA study ⻉丁酸类降脂药(Fibrate) ,⾮他汀类药物增加⾎脂异常⽼年⼈的⾎浆中的硒含量. (EVA-Etude du viellissment Arteriel ) – 01/2009
  14. Josiane Arnaud / Tasnime Akbaraly / Isabelle Hininger / Anne-Marie Roussel. Relationships between selenium, lipids, iron status and hormonal therapy in women of the SU.VIMAX cohort. 硒元素,脂肪,铁元素和⼥性荷尔蒙治疗的关系. Journal of Trace Elements in Medicine and Biology 12/ 2007
  15. Josiane Arnaud / Anne-Marie Roussel/ Serge Hercberg 等多位. Effect of Low Dose Antioxidant Vitamin and Trace Element Supplementation on the Urinary Concentrations of Thromboxane and Prostacyclin Metabolites. 低剂量抗氧化剂和微量元素补充在尿液中前列环素和⾎栓素B2的变化. Journal of American College Nutrition – 11/2007
  16. Josiane Arnaud / Muriel Bost Anne Marie ROUSSEL / 等多位. Micronutrients and cognitive impairment. 微量元素和认知功能损伤的联系. Revue de Geriatrie – 04/2007
  17. Monique Ferry / Anne-Marie Roussel.  Mitochondrial production of reactive oxygen species and incidence of ageassociated lymphoma in OF1 mice: Effect of alternate-day fasting. 线粒体能量产⽣和⽼⿏淋巴瘤在阶段型断⻝的研究. Mechanisms of Ageing and Development – 12/2005
  18. Anne-Marie Roussel / Olivier Descamps / Jacqueline Riondel / Véronique Ducros. Alterations of antioxidant trace elements (Zn, Se, Cu) and related metallo-enzymes in plasma and tissues following burn injury in rats. ⽤不同抗氧化元素和相关酶制剂对烧伤⽼⿏组织的研究. BURNS – 06/2005
  19. D Agay / R.A. Anderson / C Sandre / Yves Chancerelle / Anne-Marie ROUSSEL. Influence of Short-Chain Fructo-Oligosaccharides (sc-FOS) on Absorption of Cu, Zn, and Se in Healthy Postmenopausal Women. 短链低聚果糖对绝经期女性钙、锌和硒元素吸收的影响. Journal of the American College of Nutrition – 03/2005
  20. Véronique Ducros / Anne-Marie Roussel 等多位. Antioxidant vitamin status in high exposure to oxidative stress in competitive athletes. ⾼⽔平运动员的抗氧化元素状态研究. BRITISH JOURNAL OF NUTRITION -09/2004
  21. Anne Marie Roussel / Anne-Sophie Rousseau 等多位. Effects of a combined micronutrient supplementation on maternal biological status and newborn anthropometrics measurements: A randomized double-blind, placebocontrolled trial in apparently healthy pregnant women. 微量元素摄⼊对孕妇和新⽣⼉的⽣化变化的影响:一项对健康的孕妇中进行的随机双盲安慰剂对照试验. European Journal of Clinical Nutrition – 02/2004
  22. Anne-Marie Roussel / Isabelle Hininger /等多位. No Antioxidant Effect of Combined HRT on LDL Oxidizability and Oxidative Stress Biomarkers in Treated Post-Menopausal Women. 绝经期⼥性对氧化和抗氧化治疗的⽣化反应.Journal of the American College of Nutrition – 08/2002
  23. Anne-Marie Roussel / Isabelle Bureau / 等多位. Beneficial effect of an antioxidant micronutrient-enriched food on DNA damage: experimental study in rats using a modified comet assay in total blood. 抗氧化微量元素⻝物对DNA(基因)受损的研究 (⽼⿏⾎液研究试验). IARC Scientific publication – 02/2002
  24. Anne-Marie Roussel / Isabelle Hininger / 等多位. Trace mineral status in post menopausal women: Impact of hormonal replacement therapy. 绝经期妇⼥荷尔蒙治疗微量元素跟踪. Journal of Trace Elements in Medicine and Biology – 02/2002
  25. Anne-Marie Roussel / Isabelle Bureau / Richard A 等多位. Determinants of Blood Selenium Concentrations in France (SU.VI MAX Study). 法国人⾎液中硒元素含量.Trace Elements in Man and Animals – 01/2002
  26. Arnaud / Anne-Marie Roussel / Paul Preziosi 等多位. Oxidative Stress and Antioxidant Trace Element Status in Patients with Non-insulinDependent Diabetes. 氧化问题以及抗氧化状态在⾮胰岛素糖尿病 – 01/2002
  27. A.Kerkeni / Anne-Marie Roussel / Ali Othmane/ 等多位. Potential Antioxidant Effects of Zinc and Chromium Supplementation in People with Type 2 Diabetes Mellitus. 锌和铬补充剂对2型糖尿病患者的潜在抗氧化作用. Journal of the American College of Nutrition – 07/2001
  28. Richard A. Anderson / Anne-Marie Roussel / Nouri Zouari[…] / Abdelhamid Kerkeni. The SU.VI.MAX Study”: a primary prevention trial using nutritional doses of antioxidant vitamins and minerals in cardiovascular diseases and cancers. Supplementation on VItamines et Minéraux Antioxydants. 法国国家SU.VI.MAX研究:抗氧化、维生素、微量元素在⼼⾎管和癌症预防⽅⾯的应⽤.  Food and Chemical Toxicology – 09/1999
  29. Serge Hercberg / Paul Preziosi / Anne-Marie Roussel /等多位. Systemic Oxidative Stress and Cognitive Performance in the Population-Based EVA Study. 氧化衰⽼和认知系统在衰⽼的应⽤. Free Radical Biology and Medicine – 05/1998
  30. J Richard / Anne-Marie Roussel / C Bonithon-Kopp. Analyzed dietary intakes, plasma concentrations of zinc, copper, and selenium, and related antioxidant enzyme activities in hospitalized elderly women.住院年轻女性⾎浆中锌、铜、硒、其他微量元素,抗氧化含量和⻝物摄取之间的联系. Journal of the American College of Nutrition – 11/1996
  31. A Schmuck / Anne Marie ROUSSEL / J Arnaud / Ducros. Vitamin Intakes (A, E, C, Carotenes) In A French Institution: Assessment By The Duplicate-Diet Method. 法国人的维生素摄入量(A,E,C,胡萝卜素):采用重复饮食法进行评估. Annals of Nutrition and Metabolism – 02/1995
  32. A Poupard / Anne-Marie Roussel / J Alary. Effect of acute zinc deficiency on insulin receptor binding in rat adipocytes. 锌缺乏对于⽼⿏脂肪细胞中胰岛素的影响. Biological Trace Element Research – 05/1992
  33. Marie-Jeanne Gomot / Patrice Faure/ Anne-Marie Roussel/等多位. Effects of varying dietary proteins on plasma lipids and rabbit platelet function.不⽤饮⻝和蛋⽩质摄取对⾎液脂肪和兔⾎⼩板活化因⼦的影响. Thrombosis Research- 03/1988
  34. A Ravel / Anne-Marie Roussel / J Alary / J Laturaze. Nutritional value: Experimental analysis of effect on fat metabolism in rats.分析营养对⼩⽩⿏的代谢的影响.Jan 1980
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